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Beilstein J. Org. Chem. 2021, 17, 2377–2384, doi:10.3762/bjoc.17.154
Graphical Abstract
Figure 1: Structure of metronidazole (1).
Figure 2: Chemical structures of some metronidazole derivatives with different biological activity.
Figure 3: Crystal structure of compound 3. Colour codes: carbon = grey, mitrogen = blue, oxygen = red, hydrog...
Scheme 1: Reagents and conditions: (a) TsCl, Et3N, dry DCM, DMAP, 0 °C to room temperature, 5 h, 96%; (b) NaN3...
Figure 4: Crystal structure of 1H-1,2,3-triazole compound 5c: Colour codes: carbon = grey, nitrogen = blue, o...
Scheme 2: Reagents and conditions: (a) acid chlorides 6a–e, pyridine, dry DCM, DMAP, room temperature, 4–5 h,...
Figure 5: Crystal structures of compound 7b. Colour codes: carbon = grey, nitrogen = blue, oxygen = red, hydr...
Figure 6: General structural feature of the synthesized molecules 5.
Figure 7: The graph representing the antifungal activity of Didymella sp. against compounds 5a–i and 7a–e.
Figure 8: The graph representing the antibacterial activity of E. coli against compounds 5a–i and 7a–e.